Human thymic stromal lymphopoietin preferentially stimulates myeloid cells



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Reche, Pedro A and Soumelis, Vassili and Gorman, D M and Clifford, T and Liu, MR and Travis, M and Zurawski, Sandra M. and Johnston, J and Liu, Yong-Jun and Spits, H and Waal-Malefyt, Rene de and Kastelein, Robert A. and Bazan, Fernando (2001) Human thymic stromal lymphopoietin preferentially stimulates myeloid cells. Journal of immunology (Baltimore, Md. : 1950), 167 (1). pp. 336-343. ISSN 0022-1767

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The sequence of a novel hemopoietic cytokine was discovered in a computational screen of genomic databases, and its homology to mouse thymic stromal lymphopoietin (TSLP) suggests that it is the human orthologue. Human TSLP is proposed to signal through a heterodimeric receptor complex that consists of a new member of the hemopoietin family termed human TSLP receptor and the IL-7R alpha-chain. Cells transfected with both receptor subunits proliferated in response to purified, recombinant human TSLP, with induced phosphorylation of Stat3 and Stat5. Human TSLPR and IL-7Ralpha are principally coexpressed on monocytes and dendritic cell populations and to a much lesser extent on various lymphoid cells. In accord, we find that human TSLP functions mainly on myeloid cells; it induces the release of T cell-attracting chemokines from monocytes and, in particular, enhances the maturation of CD11c(+) dendritic cells, as evidenced by the strong induction of the costimulatory molecules CD40 and CD80 and the enhanced capacity to elicit proliferation of naive T cells.

Item Type:Article
Subjects:Medical sciences > Medicine > Immunology
Medical sciences > Biology > Biotechnology
Medical sciences > Biology > Molecular biology
ID Code:9345
Deposited On:07 Aug 2009 12:18
Last Modified:13 Dec 2018 12:48

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