Publication: Radiocirugía hipofisaria con gamma knife en perros con hiperadrenocorticismo hipofisario
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2016-08-20
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Universidad Complutense de Madrid
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Abstract
El hiperadrenocorticismo (HAC) es una de las endocrinopatías más frecuentes en la especie canina, con una incidencia aproximada de 1-2/1000 perros/año. En el 80-85% de los casos el origen se encuentra en un exceso de secreción de hormona adrenocorticotropa (ACTH) provocado por un tumor hipofisario, denominándose HAC hipofisario. En el 15-20% restante el origen del HAC es un tumor (adenoma o carcinoma) adrenocortical que secreta una cantidad excesiva de glucocorticoides, denominándose HAC adrenal, y en un escaso porcentaje de casos, la etiología se sitúa ectópicamente a ambas glándulas. En la revisión bibliográfica de esta Tesis Doctoral se proporciona una visión general de la anatomía hipofisaria en la especie canina, de la regulación y de la síntesis de las hormonas hipofisarias y adrenales que intervienen en el desarrollo del HAC. Se describen los síntomas y signos clínicos de la enfermedad, los métodos de diagnóstico y las opciones terapéuticas farmacológica, quirúrgica y radioterápica...
Spontaneous hyperadrenocorticism (HAC) is one of the most frequent endocrinopathy in dogs. Its incidence is about 1-2/1000 dogs per year. 80-85% is an HAC pituitary dependent due to an excess of adrenocorticotroph (ACTH) hormone secretion by a pituitary adenoma. In 15-20% of the cases the etiology is an adrenal tumor (adenoma or carcinoma), that produce an excess of glucorticoids, and then is called adrenal HAC. Few cases have an ectopic origin. In the review of this PhD thesis is given an overview of the canine pituitary anatomy, as well of the regulation and synthesis of the pituitary and adrenal hormones which are involved in the HAC development. It describes the disease, clinical signs and symptoms, the diagnostic methods and the pharmacological, surgical and radiotherapeutic options...
Spontaneous hyperadrenocorticism (HAC) is one of the most frequent endocrinopathy in dogs. Its incidence is about 1-2/1000 dogs per year. 80-85% is an HAC pituitary dependent due to an excess of adrenocorticotroph (ACTH) hormone secretion by a pituitary adenoma. In 15-20% of the cases the etiology is an adrenal tumor (adenoma or carcinoma), that produce an excess of glucorticoids, and then is called adrenal HAC. Few cases have an ectopic origin. In the review of this PhD thesis is given an overview of the canine pituitary anatomy, as well of the regulation and synthesis of the pituitary and adrenal hormones which are involved in the HAC development. It describes the disease, clinical signs and symptoms, the diagnostic methods and the pharmacological, surgical and radiotherapeutic options...
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Tesis inédita de la Universidad Complutense de Madrid, Facultad de Veterinaria, Departamento de Medicina y Cirugía Animal, leída el 18-01-2016