Publication: Los centenarios y sus corazones
Loading...
Files
Official URL
Full text at PDC
Publication Date
2017-02-14
Authors
Advisors (or tutors)
Editors
Journal Title
Journal ISSN
Volume Title
Publisher
Universidad Complutense de Madrid
Citations
Exportar
Abstract
Los centenarios constituyen un paradigma excepcional de envejecimiento. La población centenaria se ha incrementado rápidamente en los últimos años y las enfermedades cardiovasculares son su principal causa de muerte. Hay pocos datos sobre la anatomía cardiaca, la fisiología y fisiopatología de los centenarios, no sólo debido a la relativa escasez de este tipo de individuos, sino también porque a menudo son poco estudiados. Hipótesis de trabajo: Un buen conocimiento acerca de cómo es y cómo se comporta el corazón de las personas centenarias nos puede ayudar, tanto a comprender las razones que permiten alcanzar una edad tan elevada como, eventualmente, a prevenir y tratar las alteraciones que pudieran presentar. Objetivos. Describir el electrocardiograma (ECG), ecocardiograma y los resultados del análisis de sangre en una cohorte de personas centenarias y correlacionarlos con los datos clínicos y el pronóstico. Métodos. El estudio 4C (Caracterización Científica del Corazón del Centenario) es un registro prospectivo que reclutó a 118 personas centenarias en 9 centros españoles durante un plazo de 2 años (de abril de 2011 a marzo de 2013). La localización de los centenarios se realizó usando los medios de que cada investigador disponía, por ejemplo áreas sanitarias de cada centro/centro de salud, centenarios conocidos, centenarios dados de alta de un hospital el día de la inclusión, etc. Se completó en cada caso un protocolo preestablecido que incluía entre otros datos: una valoración geriátrica integral, un estudio clínico, analítico, electrocardiográfico y ecocardiográfico, con un seguimiento de al menos 6 meses. Se realizó un análisis descriptivo de todas las variables. Todos los análisis estadísticos se realizaron utilizando el software SPSS (V16, SPSS, Chicago, Illinois, EE.UU.)...
Centenarians are a unique paradigm of aging. The centenarian population has increased rapidly in recent years and cardiovascular diseases are the leading cause of death. There are few data on the cardiac anatomy, physiology and pathophysiology of the centenarians, not only because of the relative scarcity of such individuals but also because they are often poorly studied. Working Hypothesis: A good knowledge of how it is and how the heart of centenarians can help us both to understand the reasons that allow to reach such a high age and eventually to prevent and treat disorders that could pose behaves. Objectives. Describe the ECG, echocardiogram and blood test results in a cohort of centenarians and correlate with clinical data and prognosis. Methods. The study 4C is a prospective registry that enrolled 118 centenarians in 9 Spanish hospitals for a period of two years (April 2011 to March 2013). The location of centenarians was performed using the means available to each researcher, for example health areas of each center / health center, known centenarians, centenarians discharged from hospital the day of inclusion. It was completed in each case a predetermined protocol which included among other data: Comprehensive geriatric assessment, clinical, analytical, electrocardiographic and echocardiographic study, followed for at least 6 months was performed. A descriptive analysis of all variables was performed. All statistical analyzes were performed using SPSS software (V16, SPSS, Chicago, Illinois, USA)...
Centenarians are a unique paradigm of aging. The centenarian population has increased rapidly in recent years and cardiovascular diseases are the leading cause of death. There are few data on the cardiac anatomy, physiology and pathophysiology of the centenarians, not only because of the relative scarcity of such individuals but also because they are often poorly studied. Working Hypothesis: A good knowledge of how it is and how the heart of centenarians can help us both to understand the reasons that allow to reach such a high age and eventually to prevent and treat disorders that could pose behaves. Objectives. Describe the ECG, echocardiogram and blood test results in a cohort of centenarians and correlate with clinical data and prognosis. Methods. The study 4C is a prospective registry that enrolled 118 centenarians in 9 Spanish hospitals for a period of two years (April 2011 to March 2013). The location of centenarians was performed using the means available to each researcher, for example health areas of each center / health center, known centenarians, centenarians discharged from hospital the day of inclusion. It was completed in each case a predetermined protocol which included among other data: Comprehensive geriatric assessment, clinical, analytical, electrocardiographic and echocardiographic study, followed for at least 6 months was performed. A descriptive analysis of all variables was performed. All statistical analyzes were performed using SPSS software (V16, SPSS, Chicago, Illinois, USA)...
Description
Tesis inédita de la Universidad Complutense de Madrid, Facultad de Medicina, Departamento de Medicina, leída el 12-01-2016