Publication: Desarrollo de un generador de ⁶⁸Ge/⁶⁸Ga. Aplicaciones del ⁶⁸Ga en tomografía por emisión de positrones
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2018-02-16
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Universidad Complutense de Madrid
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Abstract
La Tomografía por Emisión de Positrones ha experimentado un gran desarrollo en los últimos años, convirtiéndose en una técnica muy importante para la investigación biomédica y el diagnóstico en clínica de forma individualizada y no invasiva para el paciente. El desarrollo y disponibilidad de nuevos radiofármacos específicos para determinadas patologías es unos de los principales promotores de la expansión de la técnica PET en clínica, en este contexto el 68Ga tiene un rol importante. Los generadores de radionucleidos pueden proporcionar de forma rutinaria radionucleidos a demanda sin depender de un acelerador o un reactor nuclear, como es el caso del 68Ga, el cual se puede obtener a través de un generador de 68Ge/68Ga. La presente tesis describe el desarrollo de un generador de 68Ge/68Ga basado en nano-SnO2 calcinado, el cual se evaluó durante un período de 1 año y 305 ciclos de elución. El rendimiento de elución fue ≥ 90% cuando el generador era nuevo, decreciendo con el tiempo y el uso de éste hasta llegar ≥ 70%, mientras que el contenido 68Ge en el eluido fue del orden de 10-4% durante todo el estudio. El generador descrito proporciona resultados satisfactorios, lo que permite utilizarlo para el marcaje de moléculas de interés en PET. Además, se describe la implementación de un método manual para la concentración y purificación del 68Ga eluido de un generador de 68Ga/68Ga, usando para ello una resina de intercambio aniónico...
Positron Emission Tomography (PET) has experienced accelerated development in the last years and has become an established method for biomedical research and clinical routine diagnostics on patient individualized basis. Development and availability of new specific radiopharmaceuticals for particular diseases is one of the driving forces of the expansion of clinical PET. In this context 68Ga has an important role. Radionuclide generators system can routinely provide radionuclides on demand without on-site availability of an accelerator or a nuclear reactor, such as 68Ga, which can be obtainable via 68Ge/68Ga generator. This thesis described the development of a radionuclide generator based on calcined nano-SnO2. This generator was evaluated over a period of 1 year and 305 elution cycles. Elution yield was ≥ 90% when the generator is new and this value decreased with time and use of it to ≥ 70%, the 68Ge content in the eluate was not exceed of 10-4% throughout the investigation period. The generator described provides satisfactory results, allowing use it for labelling molecules of interest in PET imaging. Furthermore, this thesis described a manual system based on an anion exchangecartridge for concentration and purification for 68Ga obtained of a 68Ga/68Ga generator eluate...
Positron Emission Tomography (PET) has experienced accelerated development in the last years and has become an established method for biomedical research and clinical routine diagnostics on patient individualized basis. Development and availability of new specific radiopharmaceuticals for particular diseases is one of the driving forces of the expansion of clinical PET. In this context 68Ga has an important role. Radionuclide generators system can routinely provide radionuclides on demand without on-site availability of an accelerator or a nuclear reactor, such as 68Ga, which can be obtainable via 68Ge/68Ga generator. This thesis described the development of a radionuclide generator based on calcined nano-SnO2. This generator was evaluated over a period of 1 year and 305 elution cycles. Elution yield was ≥ 90% when the generator is new and this value decreased with time and use of it to ≥ 70%, the 68Ge content in the eluate was not exceed of 10-4% throughout the investigation period. The generator described provides satisfactory results, allowing use it for labelling molecules of interest in PET imaging. Furthermore, this thesis described a manual system based on an anion exchangecartridge for concentration and purification for 68Ga obtained of a 68Ga/68Ga generator eluate...
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Tesis inédita de la Universidad Complutense de Madrid, Facultad de Farmacia, leída el 24-04-2017