Publication: Regresión del remodelado arterial coronario con un bloqueante multicanal en un modelo experimental de rata hipertensa
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2018-11-28
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Universidad Complutense de Madrid
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Abstract
La hipertensión arterial es un problema en la clínica, que produce un remodelado tanto del ventrículo izquierdo como de la vascularización coronaria. El mal control de los niveles de presión arterial se asocia a un aumento en la incidencia de insuficiencia cardiaca, isquemia miocárdica, arritmias y eventos isquémicos. La actuación sobre el remodelado cardiovascular con algunos fármacos antihipertensivos (ARA-II, IECA, calcioantagonistas y β-bloqueantes) durante un periodo de tratamiento de meses-años, disminuye la morbimortalidad en el paciente con hipertensión arterial. En un estudio experimental previo, realizado en ratas espontáneamente hipertensas (SHR), nuestro grupo demostró que elesmolol, betabloqueante cardioselectivo, produce regresión de la hipertrofia ventricular izquierda 1, así como del remodelado arterial coronario 2 tras48h de tratamiento...
Arterial hypertension is a relevant clinical issue as it produces left ventricle and coronary arteries remodeling. Unsatisfactory control of arterial pressure is associated to an increase in the incidence of cardiac failure,myocardial ischemia, arrhythmias and other ischemic events. After a long period (months to years) of treatment with some antihypertensive drugs (such as ARA-II, IECA, calcium antagonists and beta-blockers), it is seen an improvement in morbility and mortality. In a previous experimental study with spontaneously hypertensive rats (SHR), our group proved that esmolol, a cardioselective betabloker, produces an early regression of left ventricular hipertrophy 1, as well as coronary artery remodeling 2 (after just 48h of treatment)...
Arterial hypertension is a relevant clinical issue as it produces left ventricle and coronary arteries remodeling. Unsatisfactory control of arterial pressure is associated to an increase in the incidence of cardiac failure,myocardial ischemia, arrhythmias and other ischemic events. After a long period (months to years) of treatment with some antihypertensive drugs (such as ARA-II, IECA, calcium antagonists and beta-blockers), it is seen an improvement in morbility and mortality. In a previous experimental study with spontaneously hypertensive rats (SHR), our group proved that esmolol, a cardioselective betabloker, produces an early regression of left ventricular hipertrophy 1, as well as coronary artery remodeling 2 (after just 48h of treatment)...
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Tesis de la Universidad Complutense de Madrid, Facultad de Medicina, Departamento de Cirugía, leída el 17-01-2018