Publication: Ensayo clínico aleatorizado controlado y triple ciego sobre el uso de profilaxis antibiótica en la prevención de la infección postoperatoria de terceros molares mandibulares impactados
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2019-02-12
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Universidad Complutense de Madrid
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Abstract
Objetivo: Determinar la utilidad de la administración de profilaxis antibiótica (PA) para la prevención de complicaciones infecciosas e inflamatorias en la cirugía de terceros molares mandibulares impactados (TMMI).Diseño del Estudio: Ensayo clínico aleatorizado, ciego y placebo controlado.Materiales y Métodos: 120 pacientes fueron aleatorizados en 2 grupos de 60 pacientes. Al grupo experimental se le administró 2 gramos de amoxicilina 1 hora antes de la intervención, mientras que al grupo control se le administró 2 comprimidos placebo en las mismas condiciones. Los pacientes fueron controlados a los 3, 7 y 30 días.Resultados: Un 5,1% del total de pacientes operados presentó complicaciones infecciosas. Del grupo placebo 4 pacientes presentaron complicaciones infecciosas, mientras que en el grupo experimental 2 pacientes presentaron infección. Las diferencias no fueron significativas con un riesgo relativo (RR) de 0,5 (IC 95% 0.10-2.62, p>0.05) y un número necesario a tratar (NNT) de 29. Sin embargo se encontraron diferencias significativas cuando se comparó el dolor postoperatorio..
Objective: To determine the utility of the administration of antibiotic prophylaxis for the prevention of infectious and inflammatory complications in the surgery of impacted mandibular third molars.Study Design: Randomized, blinded and placebo-controlled clinical trial.Materials and Methods: 120 patients were randomized into 2 groups of 60 patients. The experimental group was administered 2 grams of amoxicillin 1 hour before the intervention, while the control group was administered 2 placebo tablets under the same conditions. The patients were monitored at 3, 7 and 30 days.Results: 5.1% of the total of operated patients presented infectious complications. From the placebo group, 4 patients presented infectious complications, while in the experimental group, 2 patients presented infection. The differences were not significant with a relative risk (RR) of 0.5 (95% CI 0.10-2.62, p> 0.05) and a number needed to treat (NNT) of 29. However, significant differences were found when comparing the postoperative pain The placebo group required more rescue medication compared to the group that received antibiotics, RR 0.49 (95% CI 0.32-0.75, p <0.05) and an NNT of 3...
Objective: To determine the utility of the administration of antibiotic prophylaxis for the prevention of infectious and inflammatory complications in the surgery of impacted mandibular third molars.Study Design: Randomized, blinded and placebo-controlled clinical trial.Materials and Methods: 120 patients were randomized into 2 groups of 60 patients. The experimental group was administered 2 grams of amoxicillin 1 hour before the intervention, while the control group was administered 2 placebo tablets under the same conditions. The patients were monitored at 3, 7 and 30 days.Results: 5.1% of the total of operated patients presented infectious complications. From the placebo group, 4 patients presented infectious complications, while in the experimental group, 2 patients presented infection. The differences were not significant with a relative risk (RR) of 0.5 (95% CI 0.10-2.62, p> 0.05) and a number needed to treat (NNT) of 29. However, significant differences were found when comparing the postoperative pain The placebo group required more rescue medication compared to the group that received antibiotics, RR 0.49 (95% CI 0.32-0.75, p <0.05) and an NNT of 3...
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Tesis inédita de la Universidad Complutense de Madrid de la Facultad de Odontología. Departamento de Especialidades Clínicas Odontológicas, leída el 7-09-2018