Publication: Determinación de células tumorales circulantes como factor pronóstico y detector de recidiva en carcinoma broncogénico no microcítico
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2019-11-11
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Universidad Complutense de Madrid
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Abstract
La alta tasa de mortalidad del cáncer de pulmón hace necesario la investigación de herramientas que pudieran mostrar interés pronóstico, como la determinación de CTCs, y que pudieran ayudar en decisiones terapéuticas y en el seguimiento.Las CTCs son células malignas liberadas desde el tumor primario y desde las metástasis al torrente sanguíneo, con supuesta capacidad metastatizante.En 1869, el Dr Ashworth realizó la primera descripción tras hallar células tumorales similares al tumor primario en la circulación de un paciente metastásico. Desde entonces, más de 50 dispositivos han sido desarrollados para detectar y aislar CTCs, cada uno con diferente metodología y resultados...
This high mortality rate of lung cancer requires the investigation of tools that could show prognostic interest, such as the determination of CTCs, and that could help us with therapeutic decisions and follow-up patterns.CTC StatusCirculating tumor cells (CTCs) are malignant cells released from primary tumor or from metastases to the bloodstream with metastasic potential.In 1869, Dr. Ashworth made the first description after isolating bloodstream tumor cells similar to primary tumor´s cells in a metastasic cancer patient. Since then, more tan 50 devices have been developed for identification and isolation of this kind of cells, each one base don different technology and providing different results...
This high mortality rate of lung cancer requires the investigation of tools that could show prognostic interest, such as the determination of CTCs, and that could help us with therapeutic decisions and follow-up patterns.CTC StatusCirculating tumor cells (CTCs) are malignant cells released from primary tumor or from metastases to the bloodstream with metastasic potential.In 1869, Dr. Ashworth made the first description after isolating bloodstream tumor cells similar to primary tumor´s cells in a metastasic cancer patient. Since then, more tan 50 devices have been developed for identification and isolation of this kind of cells, each one base don different technology and providing different results...
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Tesis inédita de la Universidad Complutense de Madrid, Facultad de Medicina, Departamento de Cirugía, leída el 24-09-2019