Publication: Medición de RANKL y OPG en fluido crevicular durante el tratamiento de ortodoncia Invisalign®, con y sin fuerzas intermitentes mediante Acceledent®
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2021-07-07
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Universidad Complutense de Madrid
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Abstract
El movimiento ortodóncico es inducido por estímulos mecánicos y facilitado por la remodelación del ligamento periodontal y el hueso alveolar. Una condición necesaria para estas acciones de remodelación ósea, y para el consecuente movimiento dentario, es la aparición de un proceso inflamatorio.
Los principales mediadores que regulan el remodelado óseo durante el tratamiento de ortodoncia son la Interleucina 1β (IL-1β), Factor de Necrosis Tumoral (TNF), Receptor Activador de factor nuclear Kappa B Ligando (RANKL), Receptor Activador de factor nuclear Kappa B (RANK) y Osteopregerina (OPG) (Kawasaki K et al., 2006, Florez-Moreno G et al., 2012, D´Apuzzo F et al., 2013).
Debido a la cada vez mayor presencia de pacientes adultos en Ortodoncia, una de las mayores inquietudes y demandas de nuestro tiempo es el interés por reducir los tiempos de tratamiento mediante la aceleración del movimiento dentario pues conlleva una serie de ventajas tanto para el paciente como para el profesional (Ryuji S et al., 2012b, Buschang P et al., 2012).
Se han experimentado diversas técnicas para acelerar el movimiento dentario: inyección de fármacos (Krishnan V and Davidovitch Z, 2009); terapias génicas (Iglesias-Linares A et al., 2011); aplicación de campos electromagnéticos o iontoforesis; estímulos vibratorios que aceleren la activación de tejidos periodontales (Ali Darendeliler M et al., 2007, Limpanichkul W et al., 2006, Murphy N et al., 2012); decorticaciones alveolares o corticotomías (Murphy N et al., 2012); variación en la intensidad de las fuerzas aplicadas (Van Leeuwen E et al., 2010); láseres de baja intensidad (Limpanichkul W et al., 2006, Yoshida T et al., 2009, Yamaguchi M et al., 2007, Fujita S et al., 2008) ; y distracción osteogénica alveolar (Nishimura M et al., 2008).
El uso de fuerzas intermitentes mediante vibración es quizás uno de los sistemas más fáciles de aceptar y llevar a cabo por el paciente.
Objetivos. Objetivo general: Analizar la relación entre la aplicación de fuerzas vibratorias intermitentes y los niveles de RANKL y OPG en fluido crevicular en pacientes con tratamiento de ortodoncia...
The orthodontic tooth movement (OTM) is induced by mechanical stimulus and facilitated by the remodeling of the periodontal ligament and the alveolar bone. A necessary condition for these actions of bone remodeling, and for the consequent tooth movement, is the appearance of an inflammatory process. The main mediators that regulate this process of bone remodeling during orthodontic treatment are Interleukin 1β (IL-1β), Tumor Necrosis Factor (TNF), Activator Receptor of nuclear factor Kappa B Ligand ( RANKL), Nuclear Factor Activating Receptor Kappa B (RANK) and Osteopregerin (OPG) (Kawasaki K et al., 2006, Florez-Moreno G et al., 2012, D'Apuzzo F et al., 2013). Due to the increasing presence of adult patients in orthodontics, one of the main concerns and demands of our time is the interest in reducing treatment times by accelerating OTM. This is due to the numerous advantages that this could bring to the orthodontist and the patient (Ryuji S et al., 2012, Buschang P et al., 2012). So far, several techniques have been experimented to accelerate OTM: injection of drugs (Krishnan K and Davidovitch Z, 2009); gene therapies (Iglesias-Linares A et al., 2011); application of electromagnetic fields or iontophoresis apparatus; vibratory stimulus that accelerate the activation of periodontal tissues (Ali Darendeliler M et al., 2007, Limpanichkul W et al., 2006, Murphy N et al., 2012); alveolar decortications or corticotomies (Murphy N et al., 2012); variation in the intensity of the applied forces (Van Leeuwen E et al., 2010); low intensity lasers (Limpanichkul W et al., 2006, Yoshida Y et al., 2009, Yamaguchi M et al., 2007, Fujita S et al., 2008); and alveolar osteogenic distraction (Nishimura M et al., 2008). The use of intermittent forces by vibration is perhaps one of the easiest systems to accept and carry out by the patient. Objetives. General objetive: Analyze the ratio between the application of intermittent vibratory forces and the levels of RANKL and OPG in saliva and crevicular fluid in patients with orthodontic treatment...
The orthodontic tooth movement (OTM) is induced by mechanical stimulus and facilitated by the remodeling of the periodontal ligament and the alveolar bone. A necessary condition for these actions of bone remodeling, and for the consequent tooth movement, is the appearance of an inflammatory process. The main mediators that regulate this process of bone remodeling during orthodontic treatment are Interleukin 1β (IL-1β), Tumor Necrosis Factor (TNF), Activator Receptor of nuclear factor Kappa B Ligand ( RANKL), Nuclear Factor Activating Receptor Kappa B (RANK) and Osteopregerin (OPG) (Kawasaki K et al., 2006, Florez-Moreno G et al., 2012, D'Apuzzo F et al., 2013). Due to the increasing presence of adult patients in orthodontics, one of the main concerns and demands of our time is the interest in reducing treatment times by accelerating OTM. This is due to the numerous advantages that this could bring to the orthodontist and the patient (Ryuji S et al., 2012, Buschang P et al., 2012). So far, several techniques have been experimented to accelerate OTM: injection of drugs (Krishnan K and Davidovitch Z, 2009); gene therapies (Iglesias-Linares A et al., 2011); application of electromagnetic fields or iontophoresis apparatus; vibratory stimulus that accelerate the activation of periodontal tissues (Ali Darendeliler M et al., 2007, Limpanichkul W et al., 2006, Murphy N et al., 2012); alveolar decortications or corticotomies (Murphy N et al., 2012); variation in the intensity of the applied forces (Van Leeuwen E et al., 2010); low intensity lasers (Limpanichkul W et al., 2006, Yoshida Y et al., 2009, Yamaguchi M et al., 2007, Fujita S et al., 2008); and alveolar osteogenic distraction (Nishimura M et al., 2008). The use of intermittent forces by vibration is perhaps one of the easiest systems to accept and carry out by the patient. Objetives. General objetive: Analyze the ratio between the application of intermittent vibratory forces and the levels of RANKL and OPG in saliva and crevicular fluid in patients with orthodontic treatment...
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Tesis inédita de la Universidad Complutense de Madrid, Facultad de Odontología. leída el 13/11/2020