Publication: Alteraciones moleculares en estadios tempranos de la enfermedad de Alzheimer: identificación de posibles biomarcadores y dianas terapéuticas
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2021-08-19
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Universidad Complutense de Madrid
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Abstract
La enfermedad de Alzheimer (EA) es una enfermedad neurodegenerativa, cuya etiopatogenia no es del todo conocida. Dentro de los mecanismos fisiopatológicos asociados con la EA, los más conocidos son los relacionados con el procesamiento de la proteína precursora de amiloide (APP),y con la hiperfosforilación de la proteína tau. Una de las vías moleculares que se ha visto alterada en la EA es la vía de las quinureninas, principal vía de degradación del triptófano. En la EA se ha descrito una activación de la vía de las quinureninas, que produce cambios en las concentraciones de sus metabolitos, como el ácido quinurénico (KYNA). Este metabolito es considerado neuroprotector, contrarresta la excitotoxidad glutamatérgica y tiene funciones antioxidantes...
Alzheimer's disease (AD) is a neurodegenerative disease with unknown etiology. The bestknown pathophysiological mechanisms in AD are those related to the amyloid precursor protein (APP) processing and tau protein hyperphosphorylation.Kynurenine pathway, the main degradative route for tryptophan, has also been found implicated in AD pathophysiology. This pathway is particularly activated in AD, resulting in changes on its downstream metabolite concentration such as kynurenic acid (KYNA). KYNA is considered neuroprotective, as it counteracts glutamatergic excitotoxicity and it may exert antioxidant functions...
Alzheimer's disease (AD) is a neurodegenerative disease with unknown etiology. The bestknown pathophysiological mechanisms in AD are those related to the amyloid precursor protein (APP) processing and tau protein hyperphosphorylation.Kynurenine pathway, the main degradative route for tryptophan, has also been found implicated in AD pathophysiology. This pathway is particularly activated in AD, resulting in changes on its downstream metabolite concentration such as kynurenic acid (KYNA). KYNA is considered neuroprotective, as it counteracts glutamatergic excitotoxicity and it may exert antioxidant functions...
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Tesis inédita de la Universidad Complutense de Madrid, Facultad de Medicina, Departamento de Medicina, leída el 09-07-2021