Publication: Análisis transcriptómico de genes de expresión inmune en cáncer de ovario seroso de alto grado usando datos de secuenciación ARN
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2022-01-26
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Universidad Complutense de Madrid
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Abstract
El cáncer de ovario (CO) es la octava causa de muerte por cáncer en mujeres(Globocan 2020) en todo el mundo. La alta tasa de mortalidad es debida a falta de pruebas de detección precoz que permitan el diagnóstico temprano de la enfermedad; lo que conlleva que la mayoría de las pacientes se diagnostican en estadios avanzados III – IV de la enfermedad. La supervivencia global a los 5 años es alrededor del 20 – 30%. El tratamiento estándar para el CO avanzado es la cirugía citoreductora de máximo esfuerzo seguida de tratamiento con quimioterapia adyuvante basada en platino. Actualmente se sabe que el cáncer de ovario es una neoplasia reactiva inmune que conlleva a una supresión linfocitaria compleja. Esta tesis propone como hipótesis que el análisis de firmas de expresión de genes inmune de muestras de tejido tumoral de las pacientes con cáncer de ovario seroso de alto grado EC III – IV podría identificar una población más susceptible de tratamiento inmunológico...
Ovarian cancer (CO) is the eighth leading cause of cancer death in women (Globocan 2020) worldwide. The high mortality rate is due to the lack of early screening tests that allow early diagnosis of the disease; this means that most patients are diagnosed in advanced stages III – IV of the disease. Overall survival at 5 years is around 20 – 30%.The standard treatment for advanced CO is maximum effort cytoreductive surgery followed by treatment with platinum-based adjuvant chemotherapy. Ovarian cancer is now known to be an immune reactive neoplasm leading to complex lymphocyte suppression. This thesis proposes as hypothesis that the analysis of immune gene expression signatures from tumor tissue samples of patients with high grade EC III – IV serous ovarian cancer could identify a population more susceptible to immune treatment....
Ovarian cancer (CO) is the eighth leading cause of cancer death in women (Globocan 2020) worldwide. The high mortality rate is due to the lack of early screening tests that allow early diagnosis of the disease; this means that most patients are diagnosed in advanced stages III – IV of the disease. Overall survival at 5 years is around 20 – 30%.The standard treatment for advanced CO is maximum effort cytoreductive surgery followed by treatment with platinum-based adjuvant chemotherapy. Ovarian cancer is now known to be an immune reactive neoplasm leading to complex lymphocyte suppression. This thesis proposes as hypothesis that the analysis of immune gene expression signatures from tumor tissue samples of patients with high grade EC III – IV serous ovarian cancer could identify a population more susceptible to immune treatment....
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Tesis inédita de la Universidad Complutense de Madrid, Facultad de Medicina, Departamento de Medicina, leída el 13-10-2021