Publication: Desarrollo y validación de sensores químicos nanoestructurados selectivos para la detección de marcadores de enfermedades respiratorias en el aliento
Loading...
Official URL
Full text at PDC
Publication Date
2022-03-18
Authors
Advisors (or tutors)
Editors
Journal Title
Journal ISSN
Volume Title
Publisher
Universidad Complutense de Madrid
Citations
Exportar
Abstract
En las últimas décadas se ha observado un incremento de personas que sufren diferentes enfermedades crónicas, debido a diversos factores como el estilo de vida, la alimentación, el estrés, la contaminación ambiental o el aumento de la esperanza de vida. En este tipo de enfermedades, un diagnóstico precoz y un buen control de la afección es muy importante para aumentar la calidad de vida del paciente y evitar posteriores exacerbaciones de la patología. Por ello, se hace necesario el desarrollo de dispositivos económicos y que de forma no invasiva se pueda realizar un diagnóstico eficaz y un control mucho más exhaustivo. Además, esta tecnología puede contribuir a una disminución del gasto sanitario a largo plazo en el tratamiento de estos pacientes, así como una mejora en la gestión de los recursos. Esta tesis doctoral está enfocada en el estudio y desarrollo de nanosensores químicos selectivos para la detección en el aliento de compuestos de interés como marcadores de enfermedades respiratorias. Debido a la complejidad de la composición del aire exhalado se han seleccionado diferentes compuestos gaseosos de interés como el monóxido de carbono (CO), óxido nítrico (NO), dióxido de nitrógeno (NO2), acetona o etanol. Estos son biomarcadores de diferentes enfermedades crónicas como el asma, la diabetes, la fibrosis quística o la enfermedad pulmonar obstructiva crónica, así como de infecciones respiratorias que puede contribuir en gran medida a un agravamiento de las afecciones anteriores. Dichas enfermedades han sido seleccionadas debido al eleva donúmero de pacientes que las padecen, y al infradiagnóstico y deficiente control existente en la actualidad...
In recent decades there has been an increase in the number of people suffering from various chronic diseases due to various factors such as lifestyle, diet, stress,environmental pollution, and increased life expectancy. Early diagnosis and effective control of the condition are essential in this type of disease to increase the patient's quality of life and avoid subsequent pathology exacerbations. For this reason, it is necessary to develop inexpensive, non-invasive devices that can provide adequate diagnosis and much more exhaustive monitoring. In addition, this technology can contribute to a decrease in long-term healthcare costs for these patients and an improvement in resource management. This doctoral thesis is focused on the study and development of selective chemical nanosensors for breath detection of compounds of interest as markers of respiratory diseases. Due to the complexity of the composition of exhaled air, different gaseous compounds of interest such as carbon monoxide (CO), nitric oxide (NO), nitrogendioxide (NO2), acetone or ethanol were selected. These are biomarkers for different chronic diseases such as asthma, diabetes, cystic fibrosis or chronic obstructive pulmonary disease, and respiratory infections that significantly aggravate the above conditions. These diseases were selected because of the high number of patients suffering from them and the current under-diagnosis and poor management...
In recent decades there has been an increase in the number of people suffering from various chronic diseases due to various factors such as lifestyle, diet, stress,environmental pollution, and increased life expectancy. Early diagnosis and effective control of the condition are essential in this type of disease to increase the patient's quality of life and avoid subsequent pathology exacerbations. For this reason, it is necessary to develop inexpensive, non-invasive devices that can provide adequate diagnosis and much more exhaustive monitoring. In addition, this technology can contribute to a decrease in long-term healthcare costs for these patients and an improvement in resource management. This doctoral thesis is focused on the study and development of selective chemical nanosensors for breath detection of compounds of interest as markers of respiratory diseases. Due to the complexity of the composition of exhaled air, different gaseous compounds of interest such as carbon monoxide (CO), nitric oxide (NO), nitrogendioxide (NO2), acetone or ethanol were selected. These are biomarkers for different chronic diseases such as asthma, diabetes, cystic fibrosis or chronic obstructive pulmonary disease, and respiratory infections that significantly aggravate the above conditions. These diseases were selected because of the high number of patients suffering from them and the current under-diagnosis and poor management...
Description
Tesis inédita de la Universidad Complutense de Madrid, Facultad de Ciencias Físicas, leída el 29-10-2021