Publication: Tratamientos farmacológicos en la coadministración de alcohol y cocaína: efectos en la expresión de genes en el córtex prefrontal de la rata
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2016-02-19
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Universidad Complutense de Madrid
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Abstract
El consumo de sustancias psicoactivas, y en concreto el consumo simultáneo de alcohol y cocaína, es una práctica frecuente en la población general. Así mismo, se ha visto que el consumo de cocaína incrementa el riesgo de desarrollar dependencia de alcohol, y viceversa. Actualmente existen 4 tratamientos farmacológicos aprobados para la dependencia de alcohol, siendo el disulfiram el primer tratamiento aprobado, posteriormente lo fueron la naltrexona y el acamprosato, y recientemente el nalmefeno. Por otra parte, estudios clínicos recientes han señalado que el topiramato, un fármaco aprobado para el tratamiento de la epilepsia y la prevención de la migraña, podría ser efectivo para el tratamiento de la dependencia de alcohol o cocaína. Sin embargo, para esta última no existe aún ninguna terapia farmacológica aprobada, y se conoce muy poco acerca de la eficacia de estas farmacoterapias en la codependencia de alcohol y cocaína...
The use of psychoactive substances, in particular the simultaneous use of alcohol and cocaine is a common practice in the general population. Likewise, it has been shown that cocaine increases the risk of alcohol dependence and vice versa. Currently there are 4 approved pharmacological treatments for alcohol dependence, being the first approved treatment disulfiram, subsequently naltrexone and acamprosate, and more recently nalmefene. Moreover, recent clinical studies have indicated that topiramate, a medication approved for the treatment of epilepsy and migraine prevention, may be effective in the treatment of alcohol or cocaine dependence. However, for the latter, there is still no approved drug therapy, and also there is very few knowledge about the efficacy of these pharmacotherapies in the co-dependency of alcohol and cocaine...
The use of psychoactive substances, in particular the simultaneous use of alcohol and cocaine is a common practice in the general population. Likewise, it has been shown that cocaine increases the risk of alcohol dependence and vice versa. Currently there are 4 approved pharmacological treatments for alcohol dependence, being the first approved treatment disulfiram, subsequently naltrexone and acamprosate, and more recently nalmefene. Moreover, recent clinical studies have indicated that topiramate, a medication approved for the treatment of epilepsy and migraine prevention, may be effective in the treatment of alcohol or cocaine dependence. However, for the latter, there is still no approved drug therapy, and also there is very few knowledge about the efficacy of these pharmacotherapies in the co-dependency of alcohol and cocaine...
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Tesis inédita de la Universidad Complutense de Madrid, Facultad de Psicología, Departamento de Psicobiología, leída el 13-01-2016