Publication: Síntesis de Fosfatos de Calcio en Presencia de Surfactantes Iónicos, Fosfolípidos y Nanopartículas de Sílice Mesoporosa para Controlar la Mesoestructura de la Biocerámica
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2016-07-19
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Universidad Complutense de Madrid
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Abstract
Actualmente, hay un gran interés en el desarrollo de nuevos biomateriales debido a su enorme contribución a las demandas de una sociedad cada vez más envejecida que necesita alternativas para el tratamiento del cáncer o las enfermedades de los tejidos duros, Los primeros biomateriales se desarrollaron para que fuesen lo más bioinertes posible, A partir de los años 70's y 80's del siglo XX, comenzaron a investigarse biomateriales bioactivos o biodegradables, incluyendo algunos fosfatos de calcio y los vidrios bioactivos, En la actualidad, el interés se enfoca hacia la síntesis de biomateriales con mesoestructura controlada y funcionalizados para mejorar y adaptar su comportamiento en el cuerpo, Por otra parte, para aplicaciones de ingeniería de tejido óseo, los biomateriales se procesan como andamios 3D capaces de ser funcionalizados con señales bioquímicas y células. Asimismo, algunas estrategias recientes para la terapia del cáncer se basan en nanopartículas mesoporosas que son capaces de transportar drogas o material genético cuando se inyectan en el torrente sanguíneo, sin ser retiradas de la circulación por los macrófagos...
Currently, there is a great interest in the development of new biomaterials because of their foreseeable enormous contribution for the demands of an aging society that needs alternatives in the treatment of hard tissues diseases or cancer. First biomaterials developed were as bioinert as possible. Then„ in the years 70's and 80's of the past Century, bioactive and biodegradable biomaterials, including calcium phosphates and bioactive glasses, started to be investigated. At present, the interest is focused towards the synthesis of biomaterials with controlled mesostructure and functionalized surface to improve and tailor at demand their behaviour into the body. Moreover, for bone tissue engineering applications, biomaterials are processed as 3D scaffolds able to be decorated with biochemical signals and cells. Nevertheless, for cancer therapy some recent strategies are based on mesoporous nanoparticles able to transport drugs or genes when injected in the blood stream, without being recognised and withdrawn by macrophages...
Currently, there is a great interest in the development of new biomaterials because of their foreseeable enormous contribution for the demands of an aging society that needs alternatives in the treatment of hard tissues diseases or cancer. First biomaterials developed were as bioinert as possible. Then„ in the years 70's and 80's of the past Century, bioactive and biodegradable biomaterials, including calcium phosphates and bioactive glasses, started to be investigated. At present, the interest is focused towards the synthesis of biomaterials with controlled mesostructure and functionalized surface to improve and tailor at demand their behaviour into the body. Moreover, for bone tissue engineering applications, biomaterials are processed as 3D scaffolds able to be decorated with biochemical signals and cells. Nevertheless, for cancer therapy some recent strategies are based on mesoporous nanoparticles able to transport drugs or genes when injected in the blood stream, without being recognised and withdrawn by macrophages...
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Tesis inédita de la Universidad Complutense de Madrid, Facultad de Farmacia, Departamento de Química Inorgánica y Bioinorgánica, leída el 10/12/2015