Publication: Proteína C reactiva, índice de conicidad y factores de riesgo cardiovascular en pacientes con diabetes tipo 2
Loading...
Official URL
Full text at PDC
Publication Date
2016-08-03
Advisors (or tutors)
Editors
Journal Title
Journal ISSN
Volume Title
Publisher
Universidad Complutense de Madrid
Citations
Exportar
Abstract
La Diabetes tipo 2, forma parte del clúster de componentes que integran el Síndrome metabólico, y constituye una enfermedad tremendamente prevalente en el mundo, con disfunciones metabólicas que incrementan la morbimortalidad. Objetivo. Con la finalidad de definir las características de una población amplia de pacientes diabéticos de la Comunidad de Madrid diagnosticados por el Hospital Infanta Leonor de Madrid, su contribución al síndrome metabólico, tipo de tratamiento, años de evolución y riesgo cardiovascular, se procedió a realizar un estudio transversal en una población de 735 diabéticos, seleccionados de una base de datos de 1135 diabéticos del Servicio de Endocrinología del Hospital de los que se disponían de datos sobre edad, género, parámetros antropométricos, glucosa, hemoglobina glicosilada, lípidos, lipoproteínas, consumo de tabaco, alcohol y actividad física. En muchos de ellos también se disponía de marcadores emergentes de afectaciones relacionadas con la diabetes y la enfermedad cardiovascular como PCR-us, microalbuminuria y fibrinógeno. Descripción de la muestra. La selección se realizó garantizando confidencialidad y que todos tuvieran datos de edad, sexo, y de los marcadores clásicos, y de la mayoría de los nuevos marcadores emergentes. Como quiera que contar absolutamente con todos los marcadores en el mismo individuo supondría perder en tal selección un número no despreciable de pacientes, se procedió a respetar la selección de 735 en donde 716 tenía información de la mayoría de los marcadores. A partir de los datos primarios se calcularon los cocientes colesterol/total /HDL-c, LDL-c/HDL-c que informan del riesgo cardiovascular, el cociente molar TG/HDL-c indicativo del tamaño de las LDL, y la relación de triglicérido- glucosa como marcador de resistencia a la insulina y riesgo de síndrome metabólico. Se procedió a calcular el riesgo cardiovascular según los algoritmos del estudio Framingham...
Type 2 diabetes mellitus is a primary component of the metabolic syndrome. Both the incidence and prevalence of type 2 diabetes are worldwide increased and associated to several metabolic diseases, which rise mortality rate. Objective: The study aims to define the characteristics of a wide Spanish diabetic population from the Infanta Leonor Hospital (Madrid) in relation to the metabolic syndrome, drug treatment, diabetes mellitus type time-course and cardiovascular risk, between others. A transversal study was performed in a population of 735 diabetic patients selected from a database of more than 1135 patients belonging to the hospital’s endocrinology service. Data of age, gender, anthropometry indicators, glucose, glycated hemoglobin A1c (HbA1c), lipids, lipoproteins, tobacco consumption, alcohol intake and physical activity were collected. Extra information on emerging indicators of future cardiovascular disease such C-reactive protein-us, microalbuminuria and fibrinogen were also available. Patients y methods: The selection was made according to hospital guidelines keeping patient confidentiality, assuring maximal possible information on classical and emergent markers. To avoid extra discard of a significant number of patients, we decided to keep the already selected 735. Information on major classical and most of emergent biomarkers was available in 716 of them. From primary data the total body mass index (MBI), the conocity index, cholesterol/HDL-c, LDL-c/HDL-c ratios informing about cardiovascular risk, the molar TG/HDL-c ratio, used as LDL size indicator, and the TyG index (the triglyceride-glucose index) surrogate insulin resistance and metabolic syndrome risk indicator were calculated. The cardiovascular risk was also assessed following Framingham score...
Type 2 diabetes mellitus is a primary component of the metabolic syndrome. Both the incidence and prevalence of type 2 diabetes are worldwide increased and associated to several metabolic diseases, which rise mortality rate. Objective: The study aims to define the characteristics of a wide Spanish diabetic population from the Infanta Leonor Hospital (Madrid) in relation to the metabolic syndrome, drug treatment, diabetes mellitus type time-course and cardiovascular risk, between others. A transversal study was performed in a population of 735 diabetic patients selected from a database of more than 1135 patients belonging to the hospital’s endocrinology service. Data of age, gender, anthropometry indicators, glucose, glycated hemoglobin A1c (HbA1c), lipids, lipoproteins, tobacco consumption, alcohol intake and physical activity were collected. Extra information on emerging indicators of future cardiovascular disease such C-reactive protein-us, microalbuminuria and fibrinogen were also available. Patients y methods: The selection was made according to hospital guidelines keeping patient confidentiality, assuring maximal possible information on classical and emergent markers. To avoid extra discard of a significant number of patients, we decided to keep the already selected 735. Information on major classical and most of emergent biomarkers was available in 716 of them. From primary data the total body mass index (MBI), the conocity index, cholesterol/HDL-c, LDL-c/HDL-c ratios informing about cardiovascular risk, the molar TG/HDL-c ratio, used as LDL size indicator, and the TyG index (the triglyceride-glucose index) surrogate insulin resistance and metabolic syndrome risk indicator were calculated. The cardiovascular risk was also assessed following Framingham score...
Description
Tesis inédita de la Universidad Complutense de Madrid, Facultad de Farmacia, Departamento de Nutrición y Bromatología I (Nutrición), leída el 01-02-2016