Publication: Morfometría craneofacial sobre ficheros DICOM. Aplicaciones en ciencias morfologicas, forenses y en cirugía reparadora
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2017-02-02
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Universidad Complutense de Madrid
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Abstract
Three-dimensional Shaping is the subject of ongoing study in disciplines like Anatomy and Anthropology. Not only does it characterize any specimen, allowing identification, but also expresses the genome, resulting in great interest in fields like Paleontology or in the diagnosis of genetic diseases. A traditional Euclidean morphometry has recently been complemented with another revolutionary technique: Geometric Morphometrics, which is able to calculate average three-dimensional shpaes (consensus) and study the variability of other subjects in relation to this one. In addition, diagnostic imaging has transformed medicine, acquiring and storing body regions. This thesis seeks to provide methodology to facilitate the implementation of the Geometric Morphometrics in Medicine, establishing the usefulness of these techniques, and comparing them. Rather than answering all the questions, it opens doors to knowledge of craniofacial morpho-geometric analysis, offering the possibility of a new two-way transfer between the clinical and morphological sciences. METHOD: High and low resolution 190 computed tomography (CT), in two series were used. Landmarks and semi-landmarks were digitized in two and three dimensions. Procrustres overlapping, main component analysis, canonical variate studies, analysis of multiple Euclidean distances, Fourier analysis, thin plate analysis, discriminant function analysis and multiple regression including geometric morphometric methods were used. The results provide, valuable data for human sex dimorphism, cranial variations with age and modularity alometry dimorphism. Geometric Morphometrics different techniques are compared and the most appropriate ones for estimating each of the parameters are listed. CONCLUSIONS DICOM databases are useful to investigate craniofacial 3D shape. Geometric Morphometrics is suitable for this purpose. Data on modern populations and future evolution of skull shape are provided. A methodological analysis and step-by-step walkthrough is provided to choose the appropriate technique for each purpose. One application of these procedures is the estimate of sexual dimorphism and the influence of age in cranial morphology, beyond the stage of development of the skull. Analysis of intracranial skull base landmarks adds additional information to the previously available. Our database provides references for the study of fragmented skulls and has clinical utility, for example, in reconstructive surgery.
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Tesis inédita de la Universidad Complutense de Madrid, Facultad de Medicina, leída el 25-01-2016