Publication: Caracterización del papel del dimorfismo y la respuesta humoral frente a Candida albicans en un modelo de colonización gastrointestinal
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2017-07-14
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Universidad Complutense de Madrid
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Abstract
Las infecciones fúngicas representan en la actualidad un problema sanitario de difícil control. El conocimiento de los factores de virulencia de los hongos patógenos que causan enfermedad es de especial relevancia en el tratamiento de candidiasis así como en el diagnóstico de las mismas. Candida albicans continúa siendo la especie patógena más prevalente, debido principalmente a su presencia como microorganismo de tipo comensal en el tracto gastrointestinal y urogenital y en la cavidad oral del ser humano. En situaciones de alteración del sistema inmunológico, C. albicans es capaz de diseminarse al torrente sanguíneo, pudiendo llegar a órganos internos causando infecciones sistémicas. Es por ello que se trata de un hongo patógeno oportunista. Uno de los aspectos más característicos de este hongo es su capacidad de presentar varias morfologías llevando a cabo la llamada transición dimórfica. Así, C. albicans puede crecer formando blastosporas, hifas, pseudohifas y clamidosporas en respuesta a determinados estímulos nutricionales y ambientales. Dicha transición dimórfica está estrechamente relacionada con sus factores de virulencia, así como en la modulación de la respuesta inmunitaria generada por el hospedador. La relación entre la filamentación y la patogenicidad de C. albicans ha sido ampliamente estudiada, mientras que las implicaciones de esta transición en su papel como comensal en el interior del tracto gastrointestinal no se conocen con precisión...
Fungal infections currently represent a health problem hard to control. Knowledge of virulence factors of pathogenic fungi that cause disease is especially important in the treatment of candidiasis and its diagnosis. Candida albicans remains the most prevalent pathogenic species, mainly due to its presence as commensal microorganism type in the gastrointestinal and urogenital tract and in the oral cavity of the human being. In situations of impaired immune system, C. albicans can disseminate to the bloodstream and can infect internal organs causing systemic infections. That is why it is considered an opportunistic fungal pathogen. One of the most characteristic aspects of this fungus is its ability to present several morphologies carrying out the dimorphic transition. Thus, C. albicans can grow forming blastospores, true hyphae, pseudohyphae and chlamydospores in response to specific nutritional and environmental stimuli. This dimorphic transition is closely related to virulence factors and to the modulation of immune response generated by the host. The relationship between filamentation and pathogenicity of C. albicans has been widely studied, while the implications of this transition in its role as a commensal inside the gastrointestinal tract is not clearly known...
Fungal infections currently represent a health problem hard to control. Knowledge of virulence factors of pathogenic fungi that cause disease is especially important in the treatment of candidiasis and its diagnosis. Candida albicans remains the most prevalent pathogenic species, mainly due to its presence as commensal microorganism type in the gastrointestinal and urogenital tract and in the oral cavity of the human being. In situations of impaired immune system, C. albicans can disseminate to the bloodstream and can infect internal organs causing systemic infections. That is why it is considered an opportunistic fungal pathogen. One of the most characteristic aspects of this fungus is its ability to present several morphologies carrying out the dimorphic transition. Thus, C. albicans can grow forming blastospores, true hyphae, pseudohyphae and chlamydospores in response to specific nutritional and environmental stimuli. This dimorphic transition is closely related to virulence factors and to the modulation of immune response generated by the host. The relationship between filamentation and pathogenicity of C. albicans has been widely studied, while the implications of this transition in its role as a commensal inside the gastrointestinal tract is not clearly known...
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Tesis inédita de la Universidad Complutense de Madrid, Facultad de Farmacia, Departamento de Microbiología II, leída el 27/10/2016