Publication: Utilización de la combinación de benzodiacepinas con un inhibidor selectivo de la recaptación de serotonina, y utilización del oligoelemento litio en el tratamiento de los trastornos de ansiedad y agresividad en perros
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2017-08-03
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Universidad Complutense de Madrid
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Abstract
La presente Tesis Doctoral estudió qué benzodiacepina (clorazepato, alprazolam) unida a fluoxetina y a un plan de modificación de conducta, se comporta mejor en los trastornos de ansiedad y agresividad en perros. Además el estudio buscó comparar una terapia farmacológica convencional con una terapia con el oligoelemento litio, para saber qué terapia se comporta mejor en los problemas de ansiedad y agresividad en perros. Se desarrollaron 3 trabajos de investigación. Todos los animales llegaron a la consulta reportando signos de ansiedad y se dividieron en 2 categorías diagnósticas según los signos presentados. En el primer trabajo, 36 perros recibieron un tratamiento farmacológico con clorazepato a dosis de 1.0 mg/kg cada 24h por 4 semanas, en conjunto con fluoxetina, administrada a dosis de 1.0mg/kg cada 24h por 10 semanas. Junto al tratamiento farmacológico los dueños siguieron un plan de modificación de conducta. En el trabajo de investigación 2, 35 perros recibieron el mismo tratamiento que los animales del experimento 1, con la excepción de que el clorazepato fue sustituido por alprazolam a dosis de 0.07 mg/kg cada 24h durante 4 semanas. En el trabajo de investigación 3, los perros se dividieron en 3 grupos, de 45 perros cada uno. El primero recibió 1 ampolla de 2ml con gluconato de litio 3 veces/día durante 10 semanas, el segundo grupo recibió una combinación farmacológica de alprazolamfluoxetina, a dosis de 0.07 mg/kg cada 24h durante 4 semanas y 1.0 mg/kg cada 24h durante 10 semanas, respectivamente. El tercer grupo solo recibió un plan de modificación de conducta durante las 10 semanas de tratamiento. Se evaluaron las mejorías de los signos de ansiedad en los animales durante los días 14, 42 y 70. Los resultados obtenidos no tuvieron una distribución normal y fueron analizados mediante pruebas no paramétricas. Ninguno de los estudios mostró diferencias significativas en cuanto a la edad, sexo y estado reproductivo de los animales...
In this doctoral thesis we studied which benzodiazepine (clorazepate, alprazolam) combined with fluoxetine and a behavior modification therapy, worked better in anxiety disorders with or without aggressive signs in dogs. The study also seeks to compare conventional pharmacological therapy, with a complementary therapy with lithium trace element, to know which one performs better on anxiety and aggressive problems in dogs. Finally. We developed three research study. All animals arrived to the animal behavior clinic showing signs of anxiety and were divided into two diagnostic categories according to the signs shown. In research study 1, 36 dogs received Clorazepato drug treatment in doses of 1.0 mg / kg every 24 h for 4 weeks, in conjunction with fluoxetine, administered in doses of 1.0mg / kg every 24 hours for 10 weeks. Also along with drug therapy owners followed a behavior modification plan since the beginning of the treatment. In research study 2, the dogs received alprazolam drug treatment in doses of 0.07 mg / kg every 24 hours for 4 weeks, combined with fluoxetine, administered in doses of 1.0 mg / kg every 24 hours for 10 weeks. As in research 1, the owners started the behavioral modification plan on their dogs the same day that pharmacological therapy started. For the last study, 53 dogs were classified and studied in the category of anxious dogs with aggression and 82 dogs were classified and studied in the category of anxious dogs without aggression. Subsequently, the studied dogs were divided into 3 groups of 45 dogs each and were given treatment. The first group received 1 blister of 2ml with lithium gluconate (T1) three times a day for 10 weeks, the second group received a drug combination with fluoxetine-alprazolam (T2) at a dose of 0.07 mg / kg every 24 hours for 4 weeks and 1.0 mg / kg every 24 hours for 10 weeks, respectively. The third group only received behavior modification plan (TC) during the 10 weeks of treatment...
In this doctoral thesis we studied which benzodiazepine (clorazepate, alprazolam) combined with fluoxetine and a behavior modification therapy, worked better in anxiety disorders with or without aggressive signs in dogs. The study also seeks to compare conventional pharmacological therapy, with a complementary therapy with lithium trace element, to know which one performs better on anxiety and aggressive problems in dogs. Finally. We developed three research study. All animals arrived to the animal behavior clinic showing signs of anxiety and were divided into two diagnostic categories according to the signs shown. In research study 1, 36 dogs received Clorazepato drug treatment in doses of 1.0 mg / kg every 24 h for 4 weeks, in conjunction with fluoxetine, administered in doses of 1.0mg / kg every 24 hours for 10 weeks. Also along with drug therapy owners followed a behavior modification plan since the beginning of the treatment. In research study 2, the dogs received alprazolam drug treatment in doses of 0.07 mg / kg every 24 hours for 4 weeks, combined with fluoxetine, administered in doses of 1.0 mg / kg every 24 hours for 10 weeks. As in research 1, the owners started the behavioral modification plan on their dogs the same day that pharmacological therapy started. For the last study, 53 dogs were classified and studied in the category of anxious dogs with aggression and 82 dogs were classified and studied in the category of anxious dogs without aggression. Subsequently, the studied dogs were divided into 3 groups of 45 dogs each and were given treatment. The first group received 1 blister of 2ml with lithium gluconate (T1) three times a day for 10 weeks, the second group received a drug combination with fluoxetine-alprazolam (T2) at a dose of 0.07 mg / kg every 24 hours for 4 weeks and 1.0 mg / kg every 24 hours for 10 weeks, respectively. The third group only received behavior modification plan (TC) during the 10 weeks of treatment...
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Tesis inédita de la Universidad Complutense de Madrid, Facultad de Veterinaria, Departamento de Producción Animal, leída el 13-06-2016