Publication: Fuente celular de la interleucina (IL)-6 y su relevancia en la regeneración hepática
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2018-03-19
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Universidad Complutense de Madrid
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Abstract
La Interleucina (IL)-6 es una citocina pleiotrópica con propiedades pro- y anti-inflamatorias, inductora de la respuesta de fase aguda, y moduladora de genes de diferenciación, supervivencia, apoptosis y proliferación celular. Aunque su importancia para la regeneración hepática tras una hepatectomía parcial (HP) está aceptada, diversos datos contradictorios han generado controversia sobre su papel. Adicionalmente, estudios recientes cuestionan el papel de las células de Kupffer (macrófagos residentes en el hígado) como responsables de la producción de IL-6 tras una HP, sugiriendo que otras células, incluyendo los hepatocitos, podrían contribuir a la misma. La hipótesis general del presente estudio fue que las células de Kupffer son la principal fuente celular de IL-6 tras la realización de una HP en ratones...
Interleukin (IL)-6 is a pleiotropic cytokine with pro- and anti-inflammatory properties, inducer of the acute phase response, and modulator of genes related to differentiation, survival, apoptosis, and cellular proliferation. Even though its importance for liver regeneration after a partial hepatectomy (PH) is well accepted, diverse contradictory data have generated controversy regarding its real role. In addition, recent studies have questioned the role of Kupffer cells (liver tissue macrophages) as main players responsible for the production of IL-6 after a PH, suggesting that other cells, including hepatocytes, may also contribute. HHYYPPOOTTHHEESSIISS The general hypothesis of the present study was that Kupffer cells are the main cellular source of IL-6 after a PH in mice. The specific hypotheses were the following: - The production of IL-6 by Kupffer cells and hepatocytes is required for the normal development of liver regeneration. - There are no relevant extrahepatic sources of IL-6 in mice after a PH...
Interleukin (IL)-6 is a pleiotropic cytokine with pro- and anti-inflammatory properties, inducer of the acute phase response, and modulator of genes related to differentiation, survival, apoptosis, and cellular proliferation. Even though its importance for liver regeneration after a partial hepatectomy (PH) is well accepted, diverse contradictory data have generated controversy regarding its real role. In addition, recent studies have questioned the role of Kupffer cells (liver tissue macrophages) as main players responsible for the production of IL-6 after a PH, suggesting that other cells, including hepatocytes, may also contribute. HHYYPPOOTTHHEESSIISS The general hypothesis of the present study was that Kupffer cells are the main cellular source of IL-6 after a PH in mice. The specific hypotheses were the following: - The production of IL-6 by Kupffer cells and hepatocytes is required for the normal development of liver regeneration. - There are no relevant extrahepatic sources of IL-6 in mice after a PH...
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Tesis inédita de la Universidad Complutense de Madrid, Facultad de Medicina, Departamento de Bioquímica y Biología Molecular III, leída el 13-06-2017