Publication: Encefalopatía hepática aguda-sobre-crónica en la colestasis microquirúrgica experimental: alteraciones metabólicas y vasculares
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2018-11-19
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Universidad Complutense de Madrid
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Abstract
Se ha realizado un estudio de la encefalopatía hepática aguda-sobre-crónica utilizando un modelo experimental colestásico para analizar la vasculopatía cerebral y el metabolismo cerebral de los aminoácidos. La encefalopatía hepática aguda-sobre-crónica es una patología, secundaria a la insuficiencia hepática aguda-sobre-crónica, que aún no ha sido bien caracterizada y entre cuyos factores etiopatogénicos se podrían encontrar la vasculopatía arterial sistémica y las alteraciones de los aminoácidos en el sistema nervioso central, motivo por el cual, los objetivos principales de este trabajo son esos dos aspectos, analizando para ello, las posibles alteraciones de factores vasoactivos en las arterias cerebrales, su repercusión sobre la arteria cerebral media y las concentraciones de aminoácidos en distintas áreas cerebrales y en el plasma...
A study of the acute-on-chronic Hepatic Encephalopathy, has been carried out by using an experimental cholestatic model to analyse the cerebral vascular disease and cerebral metabolism of amino acids. Acute-on-chronic Hepatic Encephalopathy is a pathology, secondary to acute-on-chronic liver failure, which has not yet been well characterized and among whose etiopathogenetic factors could be used to find systemic arterial vascular disease and alterations of amino acids in the central nervous system. The main objectives of this work focus on the possible alterations of vasoactive factors in cerebral arteries and its impact on the middle cerebral artery, and the concentrations of amino acids in different brain areas and in the plasma...
A study of the acute-on-chronic Hepatic Encephalopathy, has been carried out by using an experimental cholestatic model to analyse the cerebral vascular disease and cerebral metabolism of amino acids. Acute-on-chronic Hepatic Encephalopathy is a pathology, secondary to acute-on-chronic liver failure, which has not yet been well characterized and among whose etiopathogenetic factors could be used to find systemic arterial vascular disease and alterations of amino acids in the central nervous system. The main objectives of this work focus on the possible alterations of vasoactive factors in cerebral arteries and its impact on the middle cerebral artery, and the concentrations of amino acids in different brain areas and in the plasma...
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Tesis de la Universidad Complutense de Madrid, Facultad de Medicina, Departamento de Cirugía, leída el 26-06-2017