Publication: Bacteriemia relacionada con el catéter y neumonía asociada a ventilación mecánica: nuevas estrategias de erradicación del biofilm
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2019-08-01
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Universidad Complutense de Madrid
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Abstract
La bacteriemia relacionada con el catéter (BRC) y la neumonía asociada a ventilación mecánica (NAVM) son dos de las infecciones nosocomiales más importantes con alta morbi-mortalidad, altos costes asociados y prolongadas estancias hospitalarias. Ambas entidades se caracterizan por la formación de biopelículas bacterianas o fúngicas sobre la superficie de los catéteres intravasculares o de los tubos endotraqueales, respectivamente. Los biofilms confieren resistencia intrínseca a los microorganismos embebidos en estas estructuras dificultando el diagnóstico y el tratamiento de este tipo de infecciones. Por ello los principales objetivos de esta tesis son el desarrollo de nuevas aproximaciones terapéuticas para erradicar el biofilm en la BRC y en la NAVM, así como esclarecer la patogénesis de ésta última en busca de nuevos biomarcadores de diagnóstico...
Catheter-related bloodstream infection (C-RBSI) and ventilator-associated pneumonia (VAP) are two of the most important nosocomial infections related with high morbi-mortality, high associated costs and prolonged hospital stays. Both diseases are characterized by the formation of bacteria and fungal biofilms on to catheter and endotracheal tube surfaces. Biofilms confer intrinsic antimicrobial resistance to those microorganisms embedded in these structures, making these infections difficult to diagnose and to treat. Hence the aims of this study are the development of new therapeutic approaches to eradicate the biofilms implicated in C-RBSI and VAP and, to elucidate the pathogenesis of VAP caused by P. aeruginosa to find new diagnostic biomarkers...
Catheter-related bloodstream infection (C-RBSI) and ventilator-associated pneumonia (VAP) are two of the most important nosocomial infections related with high morbi-mortality, high associated costs and prolonged hospital stays. Both diseases are characterized by the formation of bacteria and fungal biofilms on to catheter and endotracheal tube surfaces. Biofilms confer intrinsic antimicrobial resistance to those microorganisms embedded in these structures, making these infections difficult to diagnose and to treat. Hence the aims of this study are the development of new therapeutic approaches to eradicate the biofilms implicated in C-RBSI and VAP and, to elucidate the pathogenesis of VAP caused by P. aeruginosa to find new diagnostic biomarkers...
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Tesis de la Universidad Complutense de Madrid, Facultad de Medicina, leída el 08/05/2019