Publication: Deterioro cognitivo y alcohol: biomarcadores y neurogénesis
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2020-04-01
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Universidad Complutense de Madrid
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Abstract
La presente Tesis Doctoral tiene como objetivo avanzar un paso más en el conocimiento del déficit cognitivo derivado del trastorno por uso de alcohol y en los mecanismos neurobiológicos que lo producen. La finalidad última de este trabajo es contribuir al progreso de las estrategias terapéuticas existentes para esta problemática y así ofrecer una mejoría en la calidad de vida de aquellas personas que sufran dicha patología.Para alcanzar este ambicioso objetivo se ha abordado la cuestión desde dos ámbitos, el clínico y el preclínico, confluyendo ambos en el análisis molecular de los datos obtenidos. En la parte clínica del estudio se contó con la participación de una cohorte de pacientes diagnosticados de trastorno por uso de alcohol (TUA), a la que se realizó una batería de evaluación neuropsicológica y se extrajo una muestra biológica para correlacionar los parámetros clínicos evaluados y los factores neurotróficos presentes en sangre. Es conveniente resaltar que los pacientes de estudio debían de presentar un período mínimo de abstinencia de un mes, de modo que los cambios descritos en las publicaciones son de carácter persistente y no provocados por la intoxicación aguda...
The present Doctoral Thesis aims to raise new knowledge about alcohol induced cognitive deficits, and its neurobiological basis. The main goal of this work is to contribute to the upgrade of the current therapeutical strategies, offering better life quality to those affected by the mentioned pathology.To reach this ambitious target, we treated the problem from two different ambits: clinical and preclinical. Biological and behavioural or sociodemographic data were analysed. Neuropsychological and biochemical data were assessed in an alcohol use disorder (AUD) patients cohort, and clinical and biological parameters like neurotrophic factors were correlated statistically. Is important to mention that patients included in our study must have been at least one month abstinents. Thus, effects described in papers are permanent, not induced by acute ethylic intoxication...
The present Doctoral Thesis aims to raise new knowledge about alcohol induced cognitive deficits, and its neurobiological basis. The main goal of this work is to contribute to the upgrade of the current therapeutical strategies, offering better life quality to those affected by the mentioned pathology.To reach this ambitious target, we treated the problem from two different ambits: clinical and preclinical. Biological and behavioural or sociodemographic data were analysed. Neuropsychological and biochemical data were assessed in an alcohol use disorder (AUD) patients cohort, and clinical and biological parameters like neurotrophic factors were correlated statistically. Is important to mention that patients included in our study must have been at least one month abstinents. Thus, effects described in papers are permanent, not induced by acute ethylic intoxication...
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Tesis inédita de la Universidad Complutense de Madrid, Facultad de Psicología, Departamento de Psicobiología, leída el 05/11/2019