Publication: Compuestos relacionados con ramoplanina producidos por actinomicetos
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2020-04-16
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Universidad Complutense de Madrid
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Abstract
Las ramoplaninas son una familia de antibióticos de tipo lipoglicodepsipéptido, de síntesis no ribosomal, estructuralmente relacionadas con los lipodepsipéptidos janiemicina, enduracidina y daptomicina, y funcionalmente con los glicopéptidos vancomicina y teicoplanina, así como con los lantibióticos mersacidina, actagardina, nisina y epidermina.La ramoplanina A2 fue descubierta a partir de una fermentación de la cepa Actinoplanes ATCC33076, aislada de una muestra de suelo recogida en la India, y como componente mayoritario de una mezcla de 3 compuestos (A1, A2 y A3) que estructuralmente solo se diferencian en la cadena lipídica que se encuentra en el residuo de Asn1 N-terminal, y que presentan actividades antimicrobianas virtualmente indistinguibles...
Ramoplanins are a family of lipoglycodepsipeptide antibiotics, of non-ribosomal synthesis (NRPS), structurally related to the lipodepsipeptides janiemycin, enduracidin and daptomycin, and functionally related to the glycopeptides vancomycin and teicoplanin, as well as with the lantibiotics mersacidin, actagardine, nisin and epidermin.Ramoplanin A2 was discovered from a fermentation broth of Actinoplanes ATCC33076, isolated from a soil sample collected in India, as a major component of a mixture of 3 compounds (A1, A2 and A3) that structurally only differ in the lipid chain found in the N-terminal Asn1 residue, and whose antimicrobial activities are virtually indistinguishable...
Ramoplanins are a family of lipoglycodepsipeptide antibiotics, of non-ribosomal synthesis (NRPS), structurally related to the lipodepsipeptides janiemycin, enduracidin and daptomycin, and functionally related to the glycopeptides vancomycin and teicoplanin, as well as with the lantibiotics mersacidin, actagardine, nisin and epidermin.Ramoplanin A2 was discovered from a fermentation broth of Actinoplanes ATCC33076, isolated from a soil sample collected in India, as a major component of a mixture of 3 compounds (A1, A2 and A3) that structurally only differ in the lipid chain found in the N-terminal Asn1 residue, and whose antimicrobial activities are virtually indistinguishable...
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Tesis inédita de la Universidad Complutense de Madrid, Facultad de Farmacia, Departamento de Microbiología II, leída el 25/11/2019