Publication: Aportaciones moleculares al diagnóstico de las multiparasitaciones por geohelmintos
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2021-04-06
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Universidad Complutense de Madrid
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Abstract
El diagnóstico de las geohelmintiasis por Ancylostoma duodenale, Necator americanus, Ascaris lumbricoides, Trichuris trichiura y Strongyloides stercoralis es actualmente uno de los grandes retos diagnósticos en parasitología, siendo además definidas por la Organización Mundial de la Salud (OMS) como las enfermedades más prevalentes dentro de las Negleted Tropical Diseases (NTDs). Actualmente el diagnóstico basado en técnicas parasitológicas convencionales para las uncinariasis, ascariasis y tricuriasis hacen necesario la puesta a punto de técnicas diagnósticas más sensibles y específicas para su correcta detección y para una mejor evaluación de los programas de control con administración masiva de fármacos establecidos por la OMS. En el caso de la estrongiloidiasis, debido a la forma de la presentación de la enfermedad (crónica con un elevado porcentaje de asintomáticos), a la carencia de una técnica de referencia “gold standard” y a la frecuencia de su aparición en nuestro país como una de las primeras causas de eosinofilia no filiada en población inmigrante y viajeros a zona endémica, este reto es aún mayor.
Los objetivos en los cuales se encuentra enmarcada esta tesis doctoral responden, de una forma seria, novedosa y actual, al problema del diagnóstico de estas patologías con que se encuentra el personal sanitario del Sistema Nacional de Salud y los investigadores cuya línea de trabajo está dirigida al estudio de estas parasitosis...
The diagnosis of soil-transmitted helminths by Ancylostoma duodenale, Necator americanus, Ascaris lumbricoides, Trichuris trichiura and Strongyloides stercoralis is currently one of the great diagnostic challenges in parasitology, being also defined by the World Health Organization (WHO) as the most prevalent diseases within the Negleted Tropical Diseases (NTDs). Currently, diagnosis based on conventional parasitological techniques for hookworms, ascariasis and trichuriasis requires the development of more sensitive and specific diagnostic techniques for their proper detection and for better evaluation of control programs with mass administration of drugs established by the WHO. In the case of strongyloidiasis due to the form of presentation of the disease (chronic with a high percentage of asymptomatic), the lack of a gold standard reference technique and the frequency of its appearance in our country as one of the first causes of non-philic eosinophilia in immigrant populations and travellers to endemic areas, this challenge is even greater. The objectives in which this doctoral thesis is framed respond, in a serious, novel and current way, to the problem of the diagnosis of these pathologies with which the sanitary personnel of the National Health System and the investigators whose line of work is directed to the study of these parasitosis find themselves...
The diagnosis of soil-transmitted helminths by Ancylostoma duodenale, Necator americanus, Ascaris lumbricoides, Trichuris trichiura and Strongyloides stercoralis is currently one of the great diagnostic challenges in parasitology, being also defined by the World Health Organization (WHO) as the most prevalent diseases within the Negleted Tropical Diseases (NTDs). Currently, diagnosis based on conventional parasitological techniques for hookworms, ascariasis and trichuriasis requires the development of more sensitive and specific diagnostic techniques for their proper detection and for better evaluation of control programs with mass administration of drugs established by the WHO. In the case of strongyloidiasis due to the form of presentation of the disease (chronic with a high percentage of asymptomatic), the lack of a gold standard reference technique and the frequency of its appearance in our country as one of the first causes of non-philic eosinophilia in immigrant populations and travellers to endemic areas, this challenge is even greater. The objectives in which this doctoral thesis is framed respond, in a serious, novel and current way, to the problem of the diagnosis of these pathologies with which the sanitary personnel of the National Health System and the investigators whose line of work is directed to the study of these parasitosis find themselves...
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Tesis inédita de la Universidad Complutense de Madrid, Facultad de Ciencias Biológicas, Departamento de Genética, Fisiología y Microbiología, leída el 14/10/2020