Publication: Atrofia de sustancia gris en el síndrome radiológico aislado: relación con alteraciones cognitivas y riesgo de conversión a esclerosis múltiple
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2021-07-07
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Universidad Complutense de Madrid
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Abstract
El Síndrome Radiológico Aislado (SRA) es una entidad de reciente descripción consistente en el hallazgo incidental de lesiones encefálicas altamente sugerentes de Esclerosis Múltiple (EM) en sujetos que carecen de síntomas o signos típicos de dicha enfermedad. El interés generado por el SRA en los últimos años es creciente dado su pronóstico incierto y las controversias en cuanto a su manejo clínico. Se estima que un tercio de estos sujetos convertirán a EM en el plazo de 5 años. Algunos estudios han detectado que, a pesar de no padecer discapacidad física, los sujetos con SRA presentan sintomatología “oculta” similar a pacientes con EM, como son deterioro cognitivo, depresión y fatiga, solo manifiesta en baterías de tests específicas, pero que repercuten negativamente sobre la calidad de vida de estos sujetos. Concretamente, el deterioro cognitivo afecta a uno de cada tres SRA, con un patrón semejante al encontrado en EM, y su valor diagnóstico y pronóstico es desconocido. En EM, el deterioro cognitivo se ha correlacionado con patología estructural cerebral predominantemente de sustancia gris (SG) tanto cortical como profunda...
The Radiologically Isolated Syndrome (RIS) is a recently described entity characterized by the incidental finding of highly suggestive Multiple Sclerosis (MS) brain lesions in subjects that lack symptoms or typical signs of the disease. The interest generated by the RIS in recent years is growing given its uncertain prognosis and the controversies regarding its clinical management. It is estimated that one third of these subjects will convert to MS within 5 years. Some studies have found that, despite not suffering from physical disability, patients with RIS have “hidden” symptoms similar to patients with MS, such as cognitive impairment, depression and fatigue, only manifested in batteries of specific tests but with a negative impact on the quality of life of these subjects. Specifically, cognitive impairment affects one in three RIS patients, with a similar pattern to that found in MS, and its diagnostic and prognostic value is still unknown. In MS, cognitive impairment has been correlated with structural brain damage predominantly in both deep and cortical gray matter (GM)...
The Radiologically Isolated Syndrome (RIS) is a recently described entity characterized by the incidental finding of highly suggestive Multiple Sclerosis (MS) brain lesions in subjects that lack symptoms or typical signs of the disease. The interest generated by the RIS in recent years is growing given its uncertain prognosis and the controversies regarding its clinical management. It is estimated that one third of these subjects will convert to MS within 5 years. Some studies have found that, despite not suffering from physical disability, patients with RIS have “hidden” symptoms similar to patients with MS, such as cognitive impairment, depression and fatigue, only manifested in batteries of specific tests but with a negative impact on the quality of life of these subjects. Specifically, cognitive impairment affects one in three RIS patients, with a similar pattern to that found in MS, and its diagnostic and prognostic value is still unknown. In MS, cognitive impairment has been correlated with structural brain damage predominantly in both deep and cortical gray matter (GM)...
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Tesis inédita de la Universidad Complutense de Madrid, Facultad de Medicina, leída el 25/01/2021