Publication: Marcadores de envejecimiento cronológico y patológico
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2021-08-31
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Universidad Complutense de Madrid
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Abstract
El envejecimiento es un proceso universal, intrínseco, progresivo y deletéreo caracterizado por la pérdida general de la función del organismo y la menor capacidad de adaptación a los cambios, esto es, por una peor homeostasis lo que se acompaña de mayor morbilidad y mortalidad. El envejecimiento presenta una alta heterogeneidad interindividual, por la que los individuos de un mismo grupo, con igual edad cronológica, no estarán envejeciendo a la misma velocidad, es decir, tendrán diferente “edad biológica”, siendo ésta mejor estimador que la edad cronológica de cómo está envejeciendo cada individuo y de su esperanza de vida. La teoría de la oxidación-inflamación postula que el envejecimiento sería resultado de un estrés oxidativo e inflamatorio crónicos que afectaría a todas las células del organismo, pero que sus consecuencias serían mayores en los sistemas homeostáticos (nervioso, endocrino e inmunitario). Además, el sistema inmunitario, por su característica de liberar compuestos oxidativos e inflamatorios para llevar a cabo su función, podría modular el estrés oxidativo-inflamatorio del organismo y consecuentemente la velocidad a la que se produce el envejecimiento...
Ageing is a universal, intrinsic, progressive and deleterious process characterized by the general loss of organismal function and by a reduced ability of adaptation to changes, i.e. a worse homeostasis maintenance, which is accompanied by increased morbidity and mortality. Ageing is characterized by a high individual heterogeneity, by which members of the same group, with the same chronological age, don’t necessarily display the same rate of ageing, also termed “biological age”, which proves to be a better estimator of how the individual is ageing and of its life expectancy, than the chronological age.The theory of oxidation-inflammation postulates that ageing would be the result of chronic oxidative and inflammatory stress that would affect all cells in the body, but that its consequences would be greater in homeostatic systems (nervous, endocrine and immune). In addition, the immune system, due to its characteristic releasing of oxidative and inflammatory compounds to perform its function, could modulate the oxidative-inflammatory stress of the body and consequently the rate at which ageing occurs...
Ageing is a universal, intrinsic, progressive and deleterious process characterized by the general loss of organismal function and by a reduced ability of adaptation to changes, i.e. a worse homeostasis maintenance, which is accompanied by increased morbidity and mortality. Ageing is characterized by a high individual heterogeneity, by which members of the same group, with the same chronological age, don’t necessarily display the same rate of ageing, also termed “biological age”, which proves to be a better estimator of how the individual is ageing and of its life expectancy, than the chronological age.The theory of oxidation-inflammation postulates that ageing would be the result of chronic oxidative and inflammatory stress that would affect all cells in the body, but that its consequences would be greater in homeostatic systems (nervous, endocrine and immune). In addition, the immune system, due to its characteristic releasing of oxidative and inflammatory compounds to perform its function, could modulate the oxidative-inflammatory stress of the body and consequently the rate at which ageing occurs...
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Tesis inédita de la Universidad Complutense de Madrid, Facultad de Ciencias Biológicas, Departamento de Genética, Fisiología y Microbiología, leída el 05-07-2021