Publication: Caracterización genómica, proteómica y de la virulencia de aislamientos clínicos de Cryptococcus neoformans var. grubii: efecto del hierro y el cobre
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2022-01-14
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Universidad Complutense de Madrid
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Abstract
Durante el desarrollo de la enfermedad fúngica invasiva (EFI), los metales participan de manera importante en la interacción entre los hongos y las células del hospedero: el hierro y el cobre actúan como cofactores en múltiples reacciones enzimáticas. Estos metales en la célula fúngica se relacionan de manera importante con la expresión de factores de virulencia gobernados por metaloproteasas [1,2]. Por otro lado, en el hospedero, son esenciales en la respuesta eficiente de mecanismos efectores, por ejemplo, en las células del sistema inmunológico. Por lo tanto, el éxito en el establecimiento de la EFI pude depender de la capacidad para competir y adquirir metales del entorno del hospedero [3,4].La levadura ambiental C. neoformans forma parte del complejo de especies que causa la criptococosis, una micosis oportunista adquirida por la inhalación de propágulos fúngicos presentes en el ambiente. Es una infección potencialmente fatal que afecta los pulmones y el sistema nervioso central [5]. Esta levadura produce infecciones frecuentemente en individuos inmunocomprometidos, por ejemplo, en pacientes con SIDA, con trasplante de órganos o con terapias inmunosupresoras...
During invasive fungal disease (IFD) development, metals play an important role in the interaction between fungi and host cells, iron, and copper act as cofactors in multiple enzymatic reactions. These metals in the fungal cell are associated to the expression of virulence factors governed by metalloproteases [1,2]. On the other hand, in the host, they are essential in the efficient response of effector mechanisms, for example, in cells of the immune system. Therefore, the success of IFD establishment may depend on the ability to acquire and compete for metals from the host environment [3,4].The environmental yeast C. neoformans is part of the species complex that causes cryptococcosis, an opportunistic mycosis, acquired by inhalation of fungal propagules present in the environment. It´s a potentially fatal infection that affects the lungs and central nervous system [5]. This yeast frequently affects immunocompromised individuals, for example, in patients with AIDS, organ transplants, or immunosuppressive therapies...
During invasive fungal disease (IFD) development, metals play an important role in the interaction between fungi and host cells, iron, and copper act as cofactors in multiple enzymatic reactions. These metals in the fungal cell are associated to the expression of virulence factors governed by metalloproteases [1,2]. On the other hand, in the host, they are essential in the efficient response of effector mechanisms, for example, in cells of the immune system. Therefore, the success of IFD establishment may depend on the ability to acquire and compete for metals from the host environment [3,4].The environmental yeast C. neoformans is part of the species complex that causes cryptococcosis, an opportunistic mycosis, acquired by inhalation of fungal propagules present in the environment. It´s a potentially fatal infection that affects the lungs and central nervous system [5]. This yeast frequently affects immunocompromised individuals, for example, in patients with AIDS, organ transplants, or immunosuppressive therapies...
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Tesis inédita de la Universidad Complutense de Madrid, Facultad de Farmacia, leída el 08-10-2021