Publication: Efecto del ciclo ovárico sobre la regulación diferencial del infiltrado de neutrófilos en el tracto reproductor femenino inferior
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2022-03-31
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Universidad Complutense de Madrid
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Abstract
El sistema inmune de la vagina tiene el reto de conciliar la presencia de microrganismos simbiontes con la presencia de espermatozoides y evitar la colonización de los patógenos de transmisión sexual. Conocemos treinta patógenos (bacterias, virus y parásitos) de transmisión por contacto sexual. Ocho de estos patógenos tienen una alta prevalencia en la población: cuatro son curables (Treponema pallidum, Neisseria gonorrhoeae, Chlamydia trachomatis y Trichomonas vaginalis) y cuatro son infecciones víricas actualmente incurables (VHB, VHS, VIH y VPH). Según la Organización Mundial de la Salud, todos los días, más de 1 millón de personas contraen infecciones de transmisión sexual en todo el mundo. Estas infecciones aumentan cada año con graves consecuencias sobre la salud, gasto sanitario y pérdida de fertilidad. Los esfuerzos actuales para entender las ITS y su interacción con el sistema inmunológico no son suficientes y se necesitan más esfuerzos para buscar soluciones imaginativas a este problema. Por esta razón, los mecanismos de regulación de la mucosa vaginal y cervical para que se produzca la reproducción y evitar el ataque de patógenos son cuestiones abiertas abordadas en este trabajo...
Vaginal immune system must reconcile the presence of symbiont microorganisms with the presence of spermatozoa and to prevent colonization by sexually transmitted pathogens. We know about thirty pathogens (bacteria, viruses, and parasites) transmitted by sexual contact. Eight of these pathogens are highly prevalent in the population: four are curable (Treponema pallidum, Neisseria gonorrhoeae, Chlamydia trachomatis and Trichomonas vaginalis) and four are currently incurable viral infections (HBV, HSV, HIV and HPV). According to the World Health Organization, every day, more than 1 million people worldwide contract sexually transmitted infections. Those infections are increasing every year with serious health consequences, health care costs and loss of fertility. Consequently, current efforts to understand STIs and their interaction with the immune system are not sufficient and more efforts are needed to seek imaginative solutions to this problem. Therefore, in this work we addressed the study of the mechanisms of vaginal and cervical mucosal regulation for reproduction to occur and prevent pathogen attack...
Vaginal immune system must reconcile the presence of symbiont microorganisms with the presence of spermatozoa and to prevent colonization by sexually transmitted pathogens. We know about thirty pathogens (bacteria, viruses, and parasites) transmitted by sexual contact. Eight of these pathogens are highly prevalent in the population: four are curable (Treponema pallidum, Neisseria gonorrhoeae, Chlamydia trachomatis and Trichomonas vaginalis) and four are currently incurable viral infections (HBV, HSV, HIV and HPV). According to the World Health Organization, every day, more than 1 million people worldwide contract sexually transmitted infections. Those infections are increasing every year with serious health consequences, health care costs and loss of fertility. Consequently, current efforts to understand STIs and their interaction with the immune system are not sufficient and more efforts are needed to seek imaginative solutions to this problem. Therefore, in this work we addressed the study of the mechanisms of vaginal and cervical mucosal regulation for reproduction to occur and prevent pathogen attack...
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Tesis inédita de la Universidad Complutense de Madrid, Facultad de Medicina, leída el 22-11-2021