Publication: Caracterización funcional del factor de transcripción Wor1 y su implicación en la adaptación al estado comensal en el patógeno oportunista Candida Albicans
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2022-04-27
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Universidad Complutense de Madrid
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Abstract
C. albicans es un microorganismo comensal, pero también un patógeno oportunista que produce infecciones superficiales y, en situaciones más graves, infecciones sistémicas que presentan una elevada tasa de mortalidad. Dado el origen endógeno de muchas de estas infecciones diseminadas, existe un interés creciente por determinar los factores permiten que este hongo se establezca como comensal. En el tracto gastrointestinal (TGI) el hongo se expone a señales y condiciones que generan una respuesta adaptativa esencial para su establecimiento. Uno de estos cambios es un aumento de la expresión de WOR1 (White-Opaque Regulator 1), el principal factor de transcripción que regula la transición de célula blanca a célula opaca, pero que también participa en la transición epigenética que sufren estas células tras su paso por el TGI. Conocer qué factores podrían estar regulando el estado comensal resulta fundamental para diseñar nuevas estrategias para prevenir y combatir las infecciones causadas por este hongo...
C. albicans is a commensal microorganism, but also an opportunistic pathogen that produces superficial infections, and in more severe situations, systemic infections with a high mortality rate. Given the endogenous origin of many of these disseminated infections, there is a growing interest in determining the factors that allow this fungus to establish as a commensal. In the gastrointestinal tract (GIT) the fungus is exposed to signals and conditions that generate an adaptive response essential for its establishment. One of these changes is an increase in the expression of WOR1 (White-Opaque Regulator 1), the main transcription factor that regulates the transition from white cell to opaque cell, but also participates in the epigenetic transition that these cells undergo after passage through the GIT. Understanding the factors that could be regulating the commensal state is essential to design new strategies to prevent and combat infections caused by this fungus...
C. albicans is a commensal microorganism, but also an opportunistic pathogen that produces superficial infections, and in more severe situations, systemic infections with a high mortality rate. Given the endogenous origin of many of these disseminated infections, there is a growing interest in determining the factors that allow this fungus to establish as a commensal. In the gastrointestinal tract (GIT) the fungus is exposed to signals and conditions that generate an adaptive response essential for its establishment. One of these changes is an increase in the expression of WOR1 (White-Opaque Regulator 1), the main transcription factor that regulates the transition from white cell to opaque cell, but also participates in the epigenetic transition that these cells undergo after passage through the GIT. Understanding the factors that could be regulating the commensal state is essential to design new strategies to prevent and combat infections caused by this fungus...
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Tesis inédita de la Universidad Complutense de Madrid, Facultad de Farmacia, leída el 25-02-2022