Publication: Influencia de aspectos morfológicos del aneurisma cerebral en el volumen de sangrado
Loading...
Official URL
Full text at PDC
Publication Date
2022-05-18
Authors
Advisors (or tutors)
Editors
Journal Title
Journal ISSN
Volume Title
Publisher
Universidad Complutense de Madrid
Citations
Exportar
Abstract
El volumen de sangrado que un aneurisma cerebral produce al romperse ha demostrado influir de manera muy relevante y negativa en el pronóstico delos pacientes con hemorragia subaracnoidea (HSA). Siendo así, es llamativo el escaso conocimiento existente sobre los factores determinantes de un mayor volumen de sangrado aneurismático. El objetivo principal es determinar la influencia de la morfología del aneurisma cerebral en el volumen de sangrado tras su ruptura. Material y métodos: Tras una revisión bibliográfica y publicación sobre el estado del arte actual, analizamos una cohorte prospectiva de pacientes que presentan HSA atendidos en el Hospital Universitario 12 de Octubre, desde el año 2008 al2020.Para el cálculo del volumen de sangrado se utiliza un método volumétrico semiautomático, cuya fiabilidad ha sido publicada por el grupo de trabajo previamente. Para el análisis detallado de la morfología 3D del aneurisma se utiliza un programa informático reciente (VMTKLab). En la segunda publicación, evaluamos la fiabilidad de este programa en sus mediciones para los primeros 40 pacientes estudiados. Para ello se compara con la prueba estándar de referencia para la morfología (arteriografía cerebral),respecto a 4 diámetros fundamentales del aneurisma. La tercera publicación evalúa la correlación entre 18 variables morfológicas, 2 variables topográficas, y 12 variables clínicodemográficas, con respecto al volumen de sangrado aneurismático, en 116pacientes...
The volume of bleeding after intracranial aneurysm rupture significantly influences the prognosis after subarachnoid hemorrhage (SAH). Despite the clinical significance of blood clot volume, factors that influence SAH volume have seldom been studied. This dissertation aims to determine the influence of the aneurysm morphology on the volume of hemorrhage after rupture. Methods: After a literature review paper addressing the current state-of-the-art, we analyzed a prospective cohort of patients presenting with SAH at the Hospital Universitario 12 de Octubre (Madrid, Spain) between 2008 and 2020. A volumetric semiautomated approach was used to determine the hemorrhage volume; its reliability has been published by our group. Accurate 3D analysis of the aneurysm morphology is achieved using anovel software (VMTKLab). In our second paper, we evaluate its reliability and accuracy by comparing the measurements obtained from the first 40 patients with the measurements obtained from the current gold standard for aneurysm morphology (cerebral angiography), concerning four main variables.The third paper evaluates the correlation between 18 morphological variables, two topographical variables, and 12 clinical-demographic variables concerning the volume of aneurysmal hemorrhage in 116 patients...
The volume of bleeding after intracranial aneurysm rupture significantly influences the prognosis after subarachnoid hemorrhage (SAH). Despite the clinical significance of blood clot volume, factors that influence SAH volume have seldom been studied. This dissertation aims to determine the influence of the aneurysm morphology on the volume of hemorrhage after rupture. Methods: After a literature review paper addressing the current state-of-the-art, we analyzed a prospective cohort of patients presenting with SAH at the Hospital Universitario 12 de Octubre (Madrid, Spain) between 2008 and 2020. A volumetric semiautomated approach was used to determine the hemorrhage volume; its reliability has been published by our group. Accurate 3D analysis of the aneurysm morphology is achieved using anovel software (VMTKLab). In our second paper, we evaluate its reliability and accuracy by comparing the measurements obtained from the first 40 patients with the measurements obtained from the current gold standard for aneurysm morphology (cerebral angiography), concerning four main variables.The third paper evaluates the correlation between 18 morphological variables, two topographical variables, and 12 clinical-demographic variables concerning the volume of aneurysmal hemorrhage in 116 patients...
Description
Tesis inédita de la Universidad Complutense de Madrid, Facultad de Medicina, Departamento de Cirugía, leída el 04-02-2022